Evaluation of Thin Layer Chromatography Image Analysis Method for Irradiated Chlorpromazine Quantification

نویسندگان

  • T. TOZAR
  • A. STOICU
  • E. RADU
  • M. L. PASCU
چکیده

We report the use of TLC image analysis software, JustTLC, for identification and quantitative evaluation of the photoproducts generated by the irradiation of Chlorpromazine water solutions with a 266 nm laser beam. The percent concentrations resulting for photoproducts from TLC analysis were compared with the relative concentrations of those identified by LC-TOF/MS measurements. The spots on the analyzed TLC plate were attributed to the corresponding photoproducts. Although LC-MS methods are more accurate, TLC can be successfully used to quantify the photoproducts obtained after exposure to UV laser radiation.

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تاریخ انتشار 2015